Pregnenolone is a steroidal hormone manufactured mainly in the adrenal glands. It is the grand precursor from which nearly all other steroid hormones are made, including DHEA, progesterone, oestrogens and testosterone. Pregnenolone seems to have a balancing effect on other hormones, being able to bring the levels of other hormones up or down as needed.

Pregnenolone, DHEA, oestrogen, progesterone, and testosterone levels decline as we age, with pregnenolone being the raw material from which all others are made.

Adrenal Function

If your adrenal glands are stressed your pregnenolone levels will drop. There are many causes of adrenal stress, including psychological stress, inadequate sleep or exercise, illness, injury or poor nutrition. Pregnenolone and DHEA are used to improve adrenal function and counteract adrenal fatigue/stress.

Symptoms of poor adrenal function/stress include low body temperature, weakness, irritability, depression, poor concentration, excess hunger, insomnia.

Before pregnancy improved adrenal function leads to improved egg quality. During pregnancy improved adrenal function gives necessary hormonal support.

Maintaining strong adrenal function is important for optimising your cortisol level, controlling blood sugar, insulin levels and overall physical fitness.

In Ireland pregnenolone is only available on foot of a prescription from your doctor. If you have any queries please contact one of our pharmacists at or 091-764185.